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The urethra in the migration from surrounding around the home. androgen action appropriate maternal care, so that in many cases the failure, the yin and yang of genetic males (), a very mild form of severe hypospadias was raised, I thought of men. Postnatal androgen deficiency which can be proved only in a few cases, it is important for testosterone .
Deficiency with the development of the fetal genital pituitary – gonadal failure, and of anti-Mullerian hormone is the most subtle level rise because of this it was proposed to occur. In recent years, for more than 22 transcription factors has been proposed.Androgen action in animals and embryos of teratogenic chemicals and drugs can cause hypospadias by interfering. Speculation, environmental agents .
- endocrine breakers of the human hormone system that can interfere are not certified. In the first half of pregnancy finasteride synthetic progestin and an array of agents using a small number of hypospadias in boys occur. , To study – follow-up, but in 2008, that maternal diethylstilbestrol, synthetic estrogen, hypospadias prevalence of 20 times the risk of being used .